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ea0063oc1.3 | Calcium and Bone | ECE2019

Menin and EZH2 activities modulate the expression of the long non-coding RNA HAR1B in parathyroid tumors

Morotti Annamaria , Verdelli Chiara , Guarnieri Vito , Muscarella Lucia Anna , Silipigni Rosa , Guerneri Silvana , Vicentini Leonardo , Vaira Valentina , Corbetta Sabrina

Epigenetic deregulation is emerging as a component of the parathyroid tumorigenesis. We identified a long non-coding RNA (LNCRNA) signature clearly distinguishing parathyroid adenomas (PAds) and carcinomas from normal glands. Among the deregulated LncRNAS, HAR1B was upregulated in PAds harboring the common chromosome 11q loss of heterozygosity (Chr11q-LOH; n=10) compared with PAds harboring normal chromosome 11 haplotype (Chr11q-WT; n=12; P&...

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ea0081ep182 | Calcium and Bone | ECE2022

Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors

Verdelli Chiara , Pio Fabrizio Federico , Tavanti Giulia Stefania , Maroni Paola , Morotti Annamaria , Guarnieri Vito , Pardi Elena , Cetani Filomena , Scillitani Alfredo , Maggiore Riccardo , Vaira Valentina , Muscarella Lucia Anna , Corbetta Sabrina

Aberrant epigenetic features occurring in parathyroid tumors involve DNA methylation, histone methylation, and non-coding RNAs. RASSF1A and APC were frequently downregulated in human cancers. Here, we investigated RASSF1A and APC methylation status in a series of parathyroid tumors from Italian patients with primary hyperparathyroidism (PAds, n=80), confirming RASSF1A and APC promoter methylation as a hallmark of sporadic parathyroi...

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Endocrine Abstracts

Menin and EZH2 activities modulate the expression of the long non-coding RNA HAR1B in parathyroid tumors

Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors

BiosciAbstracts